Studying the Mutagenicity of Red Florets Safflower IL 111 Using Ames Test
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چکیده
منابع مشابه
Mutagenicity of glutathione and cysteine in the Ames test.
Postmitochondrial supernatant from rat liver and kidney homogenates transformed cysteine into a mutagen that reverted bacteria of the strain Salmonella typhimurium TA100 to histidine independence. Glutathione was also activated by kidney postmitochondrial supernatant but not by liver preparations. Hence, important endogenous compounds of mammals are positive in the most commonly used short-term...
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The mutagenicity of ten flavonoids was assayed by the Ames test, in Salmonella typhimurium strains TA98, TA100 and TA102, with the aim of establishing hydroxylation pattern-mutagenicity relationship profiles. The compounds assessed were: quercetin, kaempferol, luteolin, fisetin, chrysin, galangin, flavone, 3-hydroxyflavone, 5-hydroxyflavone and 7-hydroxyflavone. In the Ames assay, quer...
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Driven by new regulations and animal welfare, the need to develop in silico models has increased recently as alternative approaches to safety assessment of chemicals without animal testing. This paper describes a novel machine learning ensemble approach to building an in silico model for the prediction of the Ames test mutagenicity, one of a battery of the most commonly used experimental in vit...
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The Ames Salmonella/microsome mutagenicity assay (Salmonella test; Ames test) is a short-term bacterial reverse mutation assay specifically designed to detect a wide range of chemical substances that can produce genetic damage that leads to gene mutations. The test employs several histidine dependent Salmonella strains each carrying different mutations in various genes in the histidine operon. ...
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The characterization of chemical compounds based on their molecular graphs is an important task for identifying properties such as toxicity or mutagenicity. We used different groups of topological descriptors using the AMES mutagenicity data. Instead of optimizing the classification performance, the aim of this study is to perform a structural analysis of the underlying set of molecular graphs ...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Toxicology
سال: 2006
ISSN: 1816-496X
DOI: 10.3923/jpt.2006.545.551